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D whether IGFBP3 modulates GIST cell response to imatinib, we first sought to determine whatPage 2 of(page number not for citation purposes)Molecular Cancer 2009, 8:http://www.molecular-cancer.com/content/8/1/GIST882 KIT exon 13: K642EGIST-T1 KIT exon 11: V560delYADBImatinib IGFBP3 -tubulin24 hr48 hrEImatinib IGFBP3 -tubulin24 hr48 hr-+-+-+-+3 BP F IG rhCFigure 1 Imatinib-induced IGFBP3 expression